Giovanni De Micheli
LSI Director and Professor


Sandro Carrara

Biomedical circuits and systems

Federico Angiolini
Senior Scientific Collaborator
Tuğba Kılıç
Post-doctoral Researcher


Francesca Stradolini
PhD Student




Biosensors and Biosystems Development

Contact person:
Sandro Carrara, Lecturer and Senior Scientist, EPFL-IC-LSI

Keywords: Nanotechnology, biotechnology, implantable systems, cell monitoring, human metabolism, remote powering, remote monitoring, RF communication, sensor networks

Biosensors and biosystems development is carried out in the Integrated Systems Laboratory by the Bio/interfaces Group. The group studies design technologies for circuits and systems in biomedical applications with special focus on bioelectronics and biophysics of the nano and bio structured thin molecular films integrated on micro and nano fabricated silicon chips for applications in human diagnostics, translational medicine, and biotechnology.

The research targets the design and fabrication of biosensors on chip and bio-interfaces, with target on DNA and protein based arrays. Research involves both the design of novel biosensing devices, intimate integration of highly heterogeneous systems, and development of software tools. The research is specially focused on the development of new bio/CMOS interfaces by also integrating nano- and bio- materials in the electrochemical-sensing surface. The used approach corresponds to a co-design of the different layers (bio, nano, and CMOS frontend) to improve the integration of these highly heterogeneous systems. The research foresees the design of front end circuits for both electrochemical and imaging sensors, the development of in situ computational units with biosensors, and the software algorithms for data analysis. Specific applications are in the area of implanted/on-line medical devices for continuous monitoring of human metabolism and drugs with applications in intensive care units. Other applications are in the area of full systems (including, nano/bio/sensors, electronics, and fluidics) for continuous monitoring of animal models in translational medicine and of cell cultures in biotechnology.

The goal of this broad area of research is to study innovative, multi-metabolites, highly integrated, fully connected, and real-time monitoring bio-systems for human, animal, or cell metabolism monitoring. The monitored metabolic molecules will not be limited to lactate, glucose, glutamate, ATP, and others endogenous or exogenous (e.g. drug compounds) metabolites. To pursue this aim, different projects will be focused to develop: (i) fully implantable sensors for data acquisition at molecular level; (ii) near-by stations for remote powering and signal processing; (iii) long-distance remote stations (from m to km) for data collection, management, and storage. The expected major breakthroughs in the next years of this research branch at LSI will be in the fields of: (i) multi-panel metabolites biosensors; (ii) intelligent and autonomous detectors; (iii) co-design of sensor and data acquisition electronics (iv) Analysis of biological data

Related ongoing projects:

IronIC++ (nano-tera project)

Innovative Enabling Micro-Nano-Bio-technologies for Implantable systems in molecular medicine and personalized Therapy (Sinergia SNSF project)

Tie-2-expressing monocytes: Appealing targets in breast cancer angiogenesis

Prosense: Parallel sensing of prostate cancer biomarkers



Related former projects:

i-Needle: Intelligent Needles with wireless connection to internet for Biophysical bases of Acupuncture (nano-tera project)

NutriChip: A technological platform for nutrition analysis to promote healthy food (nano-tera project)

Enabling Nano-Bio-Chip Technologies for Sensing Applications (Centre SI project)

i-Ironic: Implantable/Wearable System for on-line Monitoring of Metabolic Conditions (nano-tera project)

Nano-structured Bio-chip Development for Stem Cells Monitoring (Sino-Swiss cooperation)

Innovative Enabling Micro-Nano-Bio-Technologies for Implantable Systems in Molecular Medicine and Personalized Therapy (Sinergia SNSF project)