Modeling, Fabrication and Test of Microelectrode Arrays for in-vivo Biosensing of Pharmacological Compounds

***Archived: This is a past project,  it is not on offer at the moment!***

Contact: Mr. Andrea Cavallini, PhD Student
               Dr. Sandro Carrara, Senior Researcher


Project Description:
In recent years microelectrode arrays have been shown to enhance the sensitivity of electrochemical techniques. The employment of an array of microelectrodes connected in parallel, leads to an improved signal-to-noise ratio, and higher current densities with respect to a macroelectrode with the same surface area. A critical factor in the design of these arrays is the center-to-center separation, which must be large enough to avoid overlap of adjacent diffusion zones but not too large as to result in inefficient use of space.

Goal of the project is the definition and test of one or more optimum geometries for the fabrication of implantable microelectrode biosensors for in-vivo drug monitoring.

Project Tasks:
•    Simulation of the behavior of different geometries of microelectrode arrays for a pool of target analytes, and selection of the best ones.
•    Microfabrication of the electrodes.
•    In vitro test of the electrodes: realization of a cytochrome P450 biosensor for drug monitoring and optimization of the electrochemical technique of measurement.

Elegibility Requirements:
•    Basic knowledge on biosensors
•    Basic knowledge of lithography and microfabrication
•    Interest and motivation

***Archived: This is a past project,  it is not on offer at the moment!***